The Effect of theKampoMedicine Yokukansan on Preoperative Anxiety and Sedation Levels

Author:

Arai Young-Chang12ORCID,Kawanishi Jun1,Sakakima Yoshikazu1,Sueoka Satoshi1,Ito Akihiro1,Tawada Yusuke1,Maruyama Yuki1,Banno Shinya1,Takayama Hitomi1,Nishihara Makoto2,Kawai Takashi2ORCID,Ikemoto Tatsunori2ORCID

Affiliation:

1. Department of Surgery, Toki General Hospital, Gifu 509-5193, Japan

2. Multidisciplinary Pain Centre, School of Medicine, Aichi Medical University, 21 Karimata, Nagakutecho, Aichigun, Aichi 480-1195, Japan

Abstract

Background. Preoperative anxiety can lead to unfavorable physiological response such as tachycardia and hypertension. Prevention of preoperative anxiety improves surgical outcome and decreases inpatient stay. Yokukansan is one of prescriptions inKampo, traditional Japanese herbal medicine, and is known to exert anxiolytic effects. The aim of the present study was to compare the effects of diazepam and Yokukansan on preoperative anxiety, salivary amylase activity, and sedation levels.Methods. Seventy American Society of Anesthesiologists physical status I or II patients presenting for hemicolectomy under general anesthesia combined with epidural anesthesia were enrolled. The Diazepam group received diazepam 5 mg orally and the Yokukansan group received Yokukansan 2.5 g orally.Results. Although levels of anxiety and salivary amylase activity were not different between the two groups, the modified Observer’s Assessment of Alertness/Sedation Scale of the Yokukansan group was significantly higher compared to that of the Diazepam group.Conclusion. Yokukansan alleviated preoperative anxiety without undesirable sedation, when compared with diazepam.

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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