Effect of Probiotics Therapy on Nonalcoholic Fatty Liver Disease

Author:

Huang Yuanshe12,Wang Xiaodong3,Zhang Lai1,Zheng Ke4,Xiong Jie5,Li Jing1,Cong Chunlei1ORCID,Gong Zhaomiao3ORCID,Mao Jingxin23ORCID

Affiliation:

1. Anshun University, Guizhou, Anshun 561000, China

2. College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China

3. Chongqing Medical and Pharmaceutical College, Chongqing 400030, China

4. Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China

5. Department of Pharmacy, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders/Chongqing Key Laboratory of Pediatrics/Children’s Hospital of Chongqing Medical University, Chongqing 400014, China

Abstract

Objective. Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The pathogenesis of NAFLD is complex and multifactorial. Clinical studies have shown that alterations in the gut microbiota play a key role in NAFLD. The purpose of this study was to analyze the effect of probiotic supplementation on the treatment of NAFLD patients based on various indicators. Methods. We conducted a meta-analysis investigating the relationship between NAFLD and probiotic supplementation. Embase, PubMed, and Web of Science databases were searched by computer, and then, eligible studies were identified. Finally, a total of high-quality randomized controlled trials were selected involving 1403 participants. Meta-analysis was performed using the RevMan 5.3 software which was systematically searched for works published through Dec. 1, 2021, in the present study. Results. The meta-analysis results showed that the probiotics supplementation improved hepatocyte injury and significantly reduced the level of ALT ( P = 0.00001 ), AST ( P = 0.0009 ), GGT ( P = 0.04 ), TG ( P = 0.01 ), LDL-C ( P = 0.0005 ), HDL-C ( P = 0.0002 ), insulin ( P = 0.003 ), IR ( P = 0.03 ), BMI ( P = 0.03 ), TNF-α ( P = 0.03 ), and CRP ( P = 0.02 ), respectively, in NAFLD patients. Conclusion. The present study suggests that probiotics therapy may improve liver enzyme levels, regulated lipid metabolism, reduced insulin resistance, and improved inflammation in NAFLD patients. It supports the potential role of probiotics supplementation in the treatment of NAFLD.

Funder

Anshun University

Publisher

Hindawi Limited

Subject

Applied Mathematics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Modeling and Simulation,General Medicine

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