Effectiveness ofMentha piperitain the Treatment of Infantile Colic: A Crossover Study

Abstract

Background. Infantile colic is a distressing and common condition for which there is no proven standard treatment.Objective. To compare the efficacy ofMentha piperitawith simethicone in treatment for infantile colic.Methods. A double-blind crossover study was performed with 30 infants attending IMIP, Recife, Brazil. They were randomized to useMentha piperitaor simethicone in the treatment of infantile colic during 7 days with each drug. Primary outcomes were mother_s opinion about responses to the treatment, number of daily episodes of colic, and time spent crying, measured by a chronometer. Mann-Whitney and chi-square tests were used to compare the results. This study was previously approved by the Ethical Committee in Research at IMIP.Results. At baseline daily episodes of infantile colic was 3.9 (±1.1) and the mean crying time per day was 192 minutes (±51.6). At the end of the study daily episodes of colic fell to 1.6 (±0.6) and the crying duration decreased to 111 (±28) minutes. All mothers reported decrease of frequency and duration of the episodes of infantile colic and there were no differences between responses toMentha piperitaand simethicone.Conclusions. These findings suggest thatMentha piperitamay be used to help control infantile colic. However, these results must be repeated by others studies.