Low Survival Rates of Oral and Oropharyngeal Squamous Cell Carcinoma

Author:

Le Campion Anna Carolina Omena Vasconcellos1ORCID,Ribeiro Camila Maria Beder12ORCID,Luiz Ronir Raggio3ORCID,da Silva Júnior Francisco Feliciano1,Barros Herbert Charles Silva4ORCID,dos Santos Karine de Cássia Batista1,Ferreira Stefania Jeronimo1,Gonçalves Lucio Souza5ORCID,Ferreira Sonia Maria Soares12ORCID

Affiliation:

1. CESMAC University Center, Maceió, AL, Brazil

2. Federal University of Alagoas, Maceió, AL, Brazil

3. Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

4. State Secretary of Health (SESAU), Alagoas, Brazil

5. Post-Graduate Program in Dentistry, Estácio de Sá University, Rio de Janeiro, RJ, Brazil

Abstract

Aim. To assess the epidemiological and clinical factors that influence the prognosis of oral and oropharyngeal squamous cell carcinoma (SCC). Methods. One hundred and twenty-one cases of oral and oropharyngeal SCC were selected. The survival curves for each variable were estimated using the Kaplan-Meier method. The Cox regression model was applied to assess the effect of the variables on survival. Results. Cancers at an advanced stage were observed in 103 patients (85.1%). Cancers on the tongue were more frequent (23.1%). The survival analysis was 59.9% in one year, 40.7% in two years, and 27.8% in 5 years. There was a significant low survival rate linked to alcohol intake (p=0.038), advanced cancer staging (p=0.003), and procedures without surgery (p<0.001). When these variables were included in the Cox regression model only surgery procedures (p=0.005) demonstrated a significant effect on survival. Conclusion. The findings suggest that patients who underwent surgery had a greater survival rate compared with those that did not. The low survival rates and the high percentage of patients diagnosed at advanced stages demonstrate that oral and oropharyngeal cancer patients should receive more attention.

Funder

Department of Science and Technology, Ministry of Health

Publisher

Hindawi Limited

Subject

General Dentistry

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