Hypercalcemia in Small Lymphocytic Lymphoma with an Elevated Parathyroid Hormone-Related Peptide Associated with Early Richter Transformation-Reference-Cited by-同舟云学术

Hypercalcemia in Small Lymphocytic Lymphoma with an Elevated Parathyroid Hormone-Related Peptide Associated with Early Richter Transformation

Published:2021-04-28 Issue: Volume:2021 Page:1-4
ISSN:2090-6579
Container-title:Case Reports in Hematology
language:en
Short-container-title:Case Reports in Hematology

Author:

Bains Ashish¹^ORCID,Covas Pedro²,Timofeeva Olga³,Bromberg Michael⁴

Affiliation:

1. Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA

2. Department of Internal Medicine, George Washington University, Washington, DC, USA

3. Department of Pathology, Georgetown University Hospital, Washington, DC, USA

4. Department of Internal Medicine, Section of Hematology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA

Abstract

Hypercalcemia in malignancy is associated with multiple mechanisms and occurs in up to 20–30% of cancer patients. We report a case of small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) associated with hypercalcemia and an elevation in parathyroid hormone-related peptide (PTHrP) in the setting of a Richter transformation. Real-time reverse transcriptase PCR on lymph node biopsy specimens obtained before and after transformation showed an 8-fold increase in PTHrP mRNA levels and about 2-fold decrease in the levels of its cognate receptor PTHR1. The findings of this case suggest that parathyroid hormone-related peptide might be useful in monitoring a specific group of patients with SLL/CLL who develop hypercalcemia during the course of their disease and could suggest an autocrine-like mechanism involving PTHrP in Richter transformation.

Publisher

Hindawi Limited

Subject

Cell Biology,Developmental Biology,Embryology,Anatomy

Link

http://downloads.hindawi.com/journals/crihem/2021/5525721.pdf

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