NK Cell Subpopulation Is Altered and the Expression of TLR1 and TLR9 Is Decreased in Patients with Acute Lymphoblastic Leukemia

Author:

Sánchez-Herrera David1,Contreras-Ramos Alejandra2ORCID,Jiménez-Hernández Elva34,Medina-Sansón Aurora5,Giono-Cerezo Silvia6,Maldonado-Bernal Carmen1ORCID

Affiliation:

1. Unidad de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Dr. Márquez 162, Col. Doctores 06720, Mexico City, Mexico

2. Laboratorio de Biología del Desarrollo, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Dr. Márquez 162, Col. Doctores 06720, Mexico City, Mexico

3. Hospital Pediátrico Moctezuma, Gobierno del Distrito Federal, Servicio de Oncología, Secretaría de Salud, Oriente 158, # 189 Col. Moctezuma 2a Sección 15530, Venustiano Carranza, Mexico City, Mexico

4. Unidad de Alta Especialidad, Hospital General del Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social, Calzada Vallejo Eje 1 Pte. #208, Azcapotzalco, Mexico City, Mexico

5. Unidad de Hemato-Oncología, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Dr. Márquez 162, Col. Doctores 06720, Mexico City, Mexico

6. Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n Col, Casco de Santo Tomás 11340, Mexico City, Mexico

Abstract

NK cells represent a heterogeneous subpopulation of lymphocytes of the innate immune system, which possess powerful antitumor activity. NK cells exhibit their function through a complex collection of receptors that act synergistically to recognize, regulate, or amplify the immune response. TLRs allow cells to detect PAMPs, MAMPs, or DAMPs, which are essential for the initiation of the immune response. Studies on the different subpopulations of NK cells and their expression profile of innate immune receptors in hematological cancers are limited. In this study, the specific subpopulations of NK cells in pediatric patients with acute lymphoblastic leukemia (ALL) and the repertoire and level of expression of TLRs in cytotoxic NK cells were assessed. The results suggested that pediatric patients with ALL exhibited a significant decrease in NK cells in peripheral blood and bone marrow, in addition to alterations in the distribution of the subpopulations of cells. Regulatory and cytotoxic NK cells were diminished, whereas dysfunctional phenotype was considerably increased. Cytotoxic NK cells from children with ALL expressed all 10 TLRs, and expression of TLR1 and TLR9 was decreased compared with the controls. Interestingly, cytotoxic NK cells exhibited a higher expression of TLR1 in the bone marrow than in the peripheral blood of patients with ALL. The present study is the first to show that TLR10 was expressed in the cytotoxic NK cells and the first to assess the profile and levels of the 10 known TLRs in cytotoxic NK cells from patients with ALL. The alterations in expression levels and cellular distribution may be involved in the immune response.

Funder

Hospital Infantil de México Federico Gómez

Publisher

Hindawi Limited

Subject

Oncology

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