Affiliation:
1. Protein Chemistry, Proteomics and Epigenetic Signalling, University of Antwerp, Antwerp B-2610, Belgium
2. Laboratory of Experimental Hematology, Vaxinfectio, University of Antwerp, Antwerp B-2610, Belgium
Abstract
Neuroglobin (Ngb) is an evolutionary conserved member of the globin family with a primary expression in neurons of which the exact functions remain elusive. A plethora ofin vivoandin vitromodel systems has been generated to this day to determine the functional biological roles of Ngb. Here, we provide a comprehensive overview and discussion of the different Ngb models, covering animal and cellular models of both overexpression and knockout strategies. Intriguingly, an in-depth literature search of available Ngb expression models revealed crucial discrepancies in the outcomes observed in different models. Not only does the level of Ngb expression—either physiologically, overexpressed, or downregulated—alter its functional properties, the experimental setup, beingin vitroorin vivo, does impact the functional outcome as well and, hence, whether or not a physiological and/or therapeutic role is ascribed to Ngb. These differences could highlight either technical or biological adaptations and should be considered until elucidation of the Ngb biology.
Subject
Cell Biology,Aging,General Medicine,Biochemistry
Cited by
20 articles.
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