Affiliation:
1. Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Abstract
Ewing's sarcoma accounts for a disproportionately high portion of the overall pediatric mortality rate compared to its rare incidence in the pediatric population. Little progress has been made since the introduction of traditional chemotherapies, and understanding the biology of the tumor is critical for developing new therapies. Ewing's sarcomas rely on a functional vascular supply, which is formed by a combination of angiogenesis and vasculogenesis. Recent insights into the molecular regulation of bone marrow (BM) cell participation in vascular development have identified VEGF, SDF-1α, and DLL4 as critical players in the vasculogenesis process. Clinical trials using vascular targeting agents, specifically targeting VEGF or DLL4, are underway.
Funder
National Institutes of Health
Subject
Radiology, Nuclear Medicine and imaging,Oncology
Cited by
19 articles.
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