Significant Modules and Biological Processes between Active Components ofSalvia miltiorrhizaDepside Salt and Aspirin

Abstract

The aim of this study is to examine and compare the similarities and differences between active components ofS. miltiorrhizadepside salt and aspirin using perspective of pharmacological molecular networks. Active components ofS. miltiorrhizadepside salt and aspirin’s related genes were identified via the STITCH4.0 and GeneCards Database. A text search engine (Agilent Literature Search 2.71) and MCODE software were applied to construct network and divide modules, respectively. Finally, 32, 2, and 28 overlapping genes, modules, and pathways were identified between active components ofS. miltiorrhizadepside salt and aspirin. A multidimensional framework of drug network showed that two networks reflected commonly in human aortic endothelial cells and atherosclerosis process. Aspirin plays a more important role in metabolism, such as the well-known AA metabolism pathway and other lipid or carbohydrate metabolism pathways.S. miltiorrhizadepside salt still plays a regulatory role in type II diabetes mellitus, insulin resistance, and adipocytokine signaling pathway. Therefore, this study suggests that aspirin combined withS. miltiorrhizadepside salt may be more efficient in treatment of CHD patients, especially those with diabetes mellitus or hyperlipidemia. Further clinical trials to confirm this hypothesis are still needed.