Antioxidant and Antinociceptive Effects ofCitrus limonEssential Oil in Mice-Reference-Cited by-同舟云学术

Antioxidant and Antinociceptive Effects ofCitrus limonEssential Oil in Mice

Published:2011 Issue: Volume:2011 Page:1-8
ISSN:1110-7243
Container-title:Journal of Biomedicine and Biotechnology
language:en
Short-container-title:Journal of Biomedicine and Biotechnology

Author:

Campêlo Lidianne Mayra Lopes¹,de Almeida Antonia Amanda C.²,de Freitas Rizângela L. Mendes³,Cerqueira Gilberto Santos⁴,de Sousa Geane Felix⁵,Saldanha Gláucio Barros³,Feitosa Chistiane Mendes¹²,de Freitas Rivelilson Mendes¹

Affiliation:

1. Departmento de Bioquímica e Farmacologia, Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Pesquisa em Neuroquímica Experimental, Núcleo de Tecnologia Farmacêutica, Universidade Federal do Piauí, Teresina, PI 64049-550, Brazil

2. Departamento do Química, Centro de Ciências da Natureza, Universidade Federal do Piauí, Teresina, PI 64049-550, Brazil

3. Laboratório de Análises Clínicas, Fortaleza, CE 60430-270, Brazil

4. Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE 60430-270, Brazil

5. Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Ceará, Fortaleza, CE 60430-140, Brazil

Abstract

The antioxidant and antinociceptive activities ofCitrus limonessential oil (EO) were assessed in mice orin vitrotests. EO possesses a strong antioxidant potential according to the scavenging assays. Moreover, it presented scavenger activity against allin vitrotests. Orally, EO (50, 100, and 150 mg/kg) significantly reduced the number of writhes, and, at highest doses, it reduced the number of paw licks. Whereas naloxone antagonized the antinociceptive action of EO (highest doses), this suggested, at least, the participation of the opioid system. Further studies currently in progress will enable us to understand the action mechanisms of EO.

Publisher

Hindawi Limited

Subject

Health, Toxicology and Mutagenesis,Genetics,Molecular Biology,Molecular Medicine,General Medicine,Biotechnology

Link

http://downloads.hindawi.com/journals/bmri/2011/678673.pdf

Reference44 articles.

1. Atividade antioxidante do extrato de sementes de limão (Citrus limon) adicionado ao óleo de soja em teste de estocagem acelerada

2. Naturally occurring antinociceptive substances from plants

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