CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention-Reference-Cited by-同舟云学术

CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention

Published:2017 Issue: Volume:2017 Page:1-9
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Li Fengzhou¹²^ORCID,Zhang Shaofeng³,Zhang Qi⁴,Li Jinxiu²^ORCID,Zhao Shilei¹²,Gu Chundong¹²^ORCID

Affiliation:

1. Department of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China

2. Lung Cancer Diagnosis and Treatment Center, Dalian, Liaoning 116011, China

3. Department of Thoracic Surgery, Xingtai People’s Hospital, Xingtai, Hebei 054031, China

4. China National Research Institute of Food & Fermentation Industries, Beijing 100015, China

Abstract

CYP1B1 gene single nucleotide polymorphisms G119T, C432G, and A453G were tested among 164 NSCLC patients treated by Video-Assisted Thoracoscopic Surgery. After a follow-up period of 5 years, it was found that CYP1B1 G119T mutant genotypes were related to a higher risk of tumor recurrence and death after surgical resection. However, C432G and A453G genotypes had no influence on long-term prognosis of the study cohort. Thus, G199T alleles are supposed to be an auxiliary predictor for prognosis of NSCLC patients and a potential target for precise drug intervention, as well as a candidate for further anticancer drug research.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2017/1529564.pdf

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