Long Term Followup of Photorefractive Keratectomy with Adjuvant Use of Mitomycin C

Abstract

Purpose.To study the long term refractive and visual outcomes of photorefractive keratectomy (PRK) with intraoperative application of mitomycin C (MMC).Methods.This study included 37 eyes who received myopic PRK; after photoablation, a sponge soaked in 0.02% MMC solution was applied in all corneas for 2 minutes. Efficacy, safety, predictability, and stability of PRK MMC were evaluated. Endothelial cell density was evaluated at the last postoperative interval.Results.Mean preoperative spherical equivalent (SEQ) was−6.03±1.87 D (diopters) and reduced to−0.09±0.53 D at the last postoperative examination. Mean followup was44.73±18.24months. All the eyes were in the ±1.00 D of attempted versus achieved SEQ at the one-year follow-up interval. Furthermore, 95% of the eyes did not lose lines or gained 1 to 2 lines of CDVA, while 5% lost 1 line. At the third postoperative month, 89% of the eyes either were clear or had trace haze, while 4 eyes had mild haze; by the 12-month postoperative interval, none of the eyes demonstrated haze. Mean endothelial cell density (ECD) at the last postoperative interval was2658±153 cells/mm2.Conclusions.PRK, with intraoperative use of MMC, demonstrates stable refractive and visual outcomes up to 44 months after surgery.