Micronutrient Level Is Negatively Correlated with the Neutrophil-Lymphocyte Ratio in Patients with Severe COVID-19

Author:

Zhou Shengyu12ORCID,Zhang Fayan3ORCID,Chen Fangfang4ORCID,Li Peng5ORCID,He Yujie6ORCID,Wu Julong6ORCID,Dong Liang78ORCID,Wang Chunting9ORCID,Wang Ximing10ORCID,Zhang Wei11ORCID,Sun Wenqing12ORCID,Yin Lixia13ORCID,Zhang Rumin14ORCID,Zhao Jintong14ORCID,Sun Baoxia15ORCID

Affiliation:

1. Clinical Nursing Department, School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan, China

2. Department of Respiratory and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China

3. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China

4. Health Inspection and Testing Institute, Shandong Provincial Center for Disease Control and Prevention, Jinan, China

5. Blood Center of Shandong Province, Jinan, China

6. Institute of Virology, Shandong Provincial Center for Disease Control and Prevention, Jinan, China

7. Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China

8. The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China

9. Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

10. Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, China

11. Department of Lung Disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China

12. Department of Intensive Care Unit, Shandong Provincial Chest Hospital, Jinan, China

13. Department of Respiratory Medicine, Dezhou People’s Hospital, Dezhou, China

14. Department of Critical Care Medicine, Zibo Central Hospital, Zibo, China

15. Infectious Department, Zaozhuang Municipal Hospital, Zaozhuang, China

Abstract

Aim. To explore the potential relationship between NLR and micronutrient deficiency in patients with severe COVID-19 infection. Methods. Sixteen patients were categorized into the mild group (mild COVID-19) and severe group (severe COVID-19) based on the guideline of the management of COVID-19. The lactate dehydrogenase (LDH); superoxide dismutase (SOD), the inflammatory markers (neutrophil lymphocyte ratio (NLR)), erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), selenium (Se), iron (Fe), zinc (Zn), nickel (Ni), copper (Cu), chromium (Cr), cadmium (Cd), arsenic (As), and manganese (Mn) were measured in the blood. Results. Compared to the mild group, the NLR ( P < 0.05 ) and the level of Se ( P < 0.01 ), Fe ( P < 0.05 ), and Zn ( P < 0.05 ) were significantly decreased in the severe group. The level of Se, Fe, and Zn was significantly correlated to NLR levels. Furthermore, close positive correlation was found between NLR and severity of COVID-19. Conclusion. The micronutrient deficiency in the blood is associated with NLR in the severity of COVID-19 patients.

Funder

Key Research Project of Shandong Province

Publisher

Hindawi Limited

Subject

General Medicine

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