Atherogenic Dyslipidemia and Cardiovascular Risk Factors in Obese Children

Author:

D’Adamo Ebe1,Guardamagna Ornella2,Chiarelli Francesco3,Bartuli Andrea4ORCID,Liccardo Daniela5,Ferrari Federica6,Nobili Valerio5

Affiliation:

1. Unit of Pediatrics, Hospital of Cremona, Largo Priori 1, 26100 Cremona, Italy

2. Department of Health Science and Pediatrics, University of Turin, Piazza Polonia 94, 10126 Turin, Italy

3. Department of Pediatrics, University of Chieti, Via Dei Vestini 5, 66013 Chieti, Italy

4. Rare and Genetic Diseases Unit, Bambino Gesù Children’s Hospital, Piazza S. Onofrio 4, 00165 Rome, Italy

5. Hepatometabolic Diseases Unit, Bambino Gesù Hospital, Piazza S. Onofrio 4, 00135 Rome, Italy

6. Pediatric Department, Pediatric Gastroenterology and Liver Unit, Umberto I Hospital, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy

Abstract

Childhood obesity when associated with serum lipoprotein changes triggers atherosclerosis. Evidences suggest that the atherosclerotic process begins in childhood and that the extent of early atherosclerosis of the aorta and coronary arteries can be associated with lipoprotein levels and obesity. Furthermore, many studies in childhood demonstrate an important relationship between parameters of insulin sensitivity, body fat distribution, and the development of lipid abnormalities. This review focuses on the most recent findings on the relationship between obesity, dyslipidemia, and cardiovascular risk in children.

Publisher

Hindawi Limited

Subject

Endocrine and Autonomic Systems,Endocrinology,Endocrinology, Diabetes and Metabolism

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