Prognostic Factors of IIIAN2 Non-Small-Cell Lung Cancer after Complete Resection: A Systemic Review and Meta-analysis

Abstract

Objective and Background. We designed this systemic review meta-analysis of all the reported scientific literature to conclude the prognostic factors of IIIAN2 non-small-cell lung cancer after complete surgical resection. Management of NSCLC IIIAN2 involved different strategies, such as complete resection, chemotherapy, radiotherapy, chemoradiotherapy, and induction therapy. Each management strategy has its associated prognostic factor to monitor for better patient prognosis, recovery, survival rate, and minimize the chances of recurrence. Methods. An extensive data search was conducted from all leading databases including PubMed, Google Scholar, Embase, and Cochrane. Fifteen studies were selected according to the PRISMA model of data selected to conduct this systemic review meta-analysis. Results. Total 4444 patients were evaluated among fifteen selected studies. A number of lymph nodes involved ( $n=3965$ ), level of lymph nodes ( $n=3422$ ), and complete tumor resection ( $n=3255$ ) were the most reported prognostic factors. Conclusion. This study exhibits the overall significance of all prognostic factors of NSCLC IIIAN2 pathology for better patient management. However, other management strategies also play a significant contribution to achieving a better survival rate and less recurrence possibility.