Severe/Extreme Hypertriglyceridemia and LDL Apheretic Treatment: Review of the Literature, Original Findings

Author:

Diakoumakou Olga1,Hatzigeorgiou Georgios1,Gontoras Nikos1,Boutsikou Maria1,Kolovou Vana12,Mavrogeni Sophie1,Giannakopoulou Vassiliki1,Kolovou Genovefa D.1

Affiliation:

1. Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece

2. Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece

Abstract

Hypertriglyceridemia (HTG) is a feature of numerous metabolic disorders including dyslipidemias, metabolic syndrome, and diabetes mellitus type 2 and can increase the risk of premature coronary artery disease. HTG may also be due to genetic factors (called primary HTG) and particularly the severe/extreme HTG (SEHTG), which is a usually rare genetic disorder. Even rarer are secondary cases of SEHTG caused by autoimmune disease. This review considers the causes of SEHTG, and their management including treatment with low density lipoprotein apheresis and analyzes the original findings.

Publisher

Hindawi Limited

Subject

Organic Chemistry,Hematology,Endocrinology, Diabetes and Metabolism,Internal Medicine

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