Clear Cell Carcinoma of the Endometrium Causing Paraneoplastic Retinopathy: Case Report and Review of the Literature

Author:

Cybulska Paulina1,Navajas Eduardo V.2,Altomare Filiberto2,Bernardini Marcus Q.3

Affiliation:

1. Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada M5G 0A3

2. Department of Ophthalmology and Vision Sciences, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada M5G 2M9

3. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada M5G 2M9

Abstract

We reviewed the literature for cases in which gynecologic malignancies caused paraneoplastic retinopathy and ultimately led to blindness. Twenty-eight cases were derived from the literature, and one unique case is described from our institution. Of these 28 cases, 14 patients were diagnosed with endometrial cancer, 7 with ovarian cancer, 5 with cervical cancer, 1 fallopian tube cancer and 1 with concomitant endometrial and ovarian cancers. The average age of patients at the time of diagnosis was 64 years (range, 35–89 years). Typically, ocular manifestations antedate symptoms of the underlying carcinoma by 3–12 months. Information regarding the interval from visual symptoms to time of death is limited, but ranges from several months to several years. Our report is the first to document a clear cell carcinoma of the endometrium causing paraneoplastic retinopathy and is the first to review all gynecologic malignancies associated with visual paraneoplastic syndromes.

Publisher

Hindawi Limited

Subject

Obstetrics and Gynaecology

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Unique and progressive retinal degeneration in a patient with cancer associated retinopathy;American Journal of Ophthalmology Case Reports;2020-12

2. The diagnostic usefulness of the negative electroretinogram;Archivos de la Sociedad Española de Oftalmología (English Edition);2018-03

3. La utilidad diagnóstica del electrorretinograma negativo;Archivos de la Sociedad Española de Oftalmología;2018-03

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