Central Nervous System Cell-Derived Exosomes in Neurodegenerative Diseases

Author:

Tian Yang1ORCID,Fu Chen1,Wu Yifan1,Lu Yao1,Liu Xuemei1ORCID,Zhang Yunling2ORCID

Affiliation:

1. Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China

2. Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China

Abstract

Exosomes are a type of extracellular vesicles secreted by almost all kinds of mammalian cells that shuttle “cargo” from one cell to another, indicative of its role in cell-to-cell transportation. Interestingly, exosomes are known to undergo alterations or serve as a pathway in multiple diseases, including neurodegenerative diseases. In the central nervous system (CNS), exosomes originating from neurons or glia cells contribute to or inhibit the progression of CNS-related diseases in special ways. In lieu of this, the current study investigated the effect of CNS cell-derived exosomes on different neurodegenerative diseases.

Funder

NATCM TCM Inheritance and Innovation “Hundred-Thousand-Ten Thousand” Talents Project (QiHuang Scholar)——National TCM Leading Personnel Support Program (NATCM Personnel and Education Department

Publisher

Hindawi Limited

Subject

Cell Biology,Ageing,General Medicine,Biochemistry

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