The Th17/IL-23 Axis and Natural Immunity in Psoriatic Arthritis

Author:

Maeda Shinji1,Hayami Yoshihito1,Naniwa Taio1,Ueda Ryuzo1

Affiliation:

1. Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan

Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory skin disease that causes enthesitis and destructive arthritis and significantly lowers patient quality of life. Recognition of the two target organs (the skin and joints) involved in the immunopathophysiology of PsA helped in elucidating the pathology of various systemic autoimmune diseases targeting multiple organs. Recent advances in immunology and genetics have made it clear that acquired immunity, especially that mediated by the Th17/IL-23 axis, plays an important role in the inflammatory pathology observed in psoriasis and PsA. Additionally, involvement of natural immunity has also been suggested. Microbial infection has been known to trigger psoriasis and PsA. Recent clinical studies using biopharmaceuticals, such as tumor-necrosis-factor- (TNF-)αinhibitors and IL-12/23 p40 antibodies, indicate that studies need not be based only on the immunological phenomena observed in PsA pathology since disease pathology can now be verified using human-based science. Considering this aspect, this paper discusses the immunopathology of PsA compared to psoriasis (cutaneous) and rheumatoid arthritis in humans and immunopathology of PsA with respect to the Th17/IL-23 axis and microbial infection.

Publisher

Hindawi Limited

Subject

Immunology,Rheumatology

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1. Inflammatory Cytokines in Psoriatic Arthritis: Understanding Pathogenesis and Implications for Treatment;International Journal of Molecular Sciences;2023-07-19

2. Transcriptional regulation on effector T cells in the pathogenesis of psoriasis;European Journal of Medical Research;2023-06-03

3. Phospholipase A1 Member A Deficiency Alleviates Mannan-Induced Psoriatic Arthritis in Mice Model;International Journal of Molecular Sciences;2022-08-02

4. Regulation of bone mass in inflammatory diseases;Best Practice & Research Clinical Endocrinology & Metabolism;2021-12

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