Structural Features of Antitumor Titanium Agents and Related Compounds-Reference-Cited by-同舟云学术

Structural Features of Antitumor Titanium Agents and Related Compounds

Published:2005 Issue:3-4 Volume:3 Page:317-329
ISSN:1565-3633
Container-title:Bioinorganic Chemistry and Applications
language:en
Short-container-title:Bioinorganic Chemistry and Applications

Author:

Caruso Francesco¹,Rossi Miriam²,Opazo Cristian³,Pettinari Claudio⁴

Affiliation:

1. Instituto di Chimica Biomolecolare, CNR, Piazzale Aldo Moro, 5, Rome 00185, Italy

2. Vassar College, Department of Chemistry, Poughkeepsie 12604-0484, NY, USA

3. Vassar College, SCIVIS laboratory, Poughkeepsie 12604-0724, NY, USA

4. Università di Camerino, Facoltà di Scienze Chimiche, Via S. Agostino 1, Camerino (MC), Italy

Abstract

Previous studies established some Ti compounds as having marked activity against tumors of the gastrointestinal tract and lack of side effects common to widely used cytostatic agents. We describe pertinent structural features of known antitumor Ti agents and other potentially active compounds. Particularly noteworthy features are thatTi-Obonds are short andTi-O-Tibond angles are large, demonstrating that in these compounds the O binding has high s-character approaching sp hybridization.

Publisher

Hindawi Limited

Subject

Inorganic Chemistry,Organic Chemistry,Biochemistry

Link

http://downloads.hindawi.com/journals/bca/2005/309076.pdf

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