Bifurcation Analysis of Periodic Oscillation in a Hematopoietic Stem Cells Model with Time Delay Control

Abstract

Underlying the state feedback control, the complex dynamical disease of the hematopoietic stem cells model based on Mackey’s mathematical description is analyzed. The bifurcating periodical oscillation solutions of the system are continued by applying numerical simulation method. The limit point cycle bifurcation and period doubling bifurcation are observed frequently in the continuation process. The attraction basins of the positive equilibrium solution shrink as the differentiate rate is ascending and the observed Mobiüs strain is simulated with boundary as the period-2 solution. The period doubling bifurcation leads to period-2, period-4, and period-8 solutions which are simulated. Starting from period doubling bifurcation point, the continuation of the bifurcating solution routes to homoclinic solution is finished. The simulation results improve the comprehension related to the spontaneous dynamical character manifested in the hematopoietic stem cells model.