HMG-CoA Reductase Inhibitors fromMonascus-Fermented Rice

Abstract

Seven compounds were isolated fromMonascus-fermented rice by column chromatography with silica gel and semiprep HPLC. Their structures were elucidated by extensive spectroscopic methods. All compounds displayed HMG-CoA reductase inhibitory potential, among them compound7exhibited strong inhibition with IC50value comparable with lovastatin. In this study, two compounds (1and2) were obtained from natural source for the first time.