Stretching Training Rehabilitation Has Potential to Alleviate Ankylosing Spondylitis in Mice by Inactivating the Wnt/β-Catenin Pathway

Author:

Xie Yu1,Li Xiang2,Zhang Qiuchi3,Guo Feng1,Wang Yue1ORCID

Affiliation:

1. Affiliated Hospital of Nanjing University of Chinese Medicine (Rheumatology Department, Jiangsu Province Hospital of Chinese Medicine), Nanjing 210029, China

2. Nanjing University of Chinese Medicine, Nanjing 210046, China

3. Affiliated Hospital of Nanjing University of Chinese Medicine (Neurology Department, Jiangsu Province Hospital of Chinese Medicine), Nanjing 210029, China

Abstract

Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by invasion of the joints of the central axis that involves soft tissues and joints surrounding the spine. Stretching training rehabilitation (STR) has been widely applied for the treatment of AS. The Wnt/β-catenin signalling pathway is closely related to AS. In this study, we aimed to explore the potential molecular mechanisms underlying the protective effect of STR on AS both in vitro and in vivo. Male DBA/1 mice were employed to establish an AS animal model. Hematoxylin-eosin staining showed that STR reversed pathological damages in bone tissues and the total antioxidant capacity of AS mice and increased the antioxidant capacity by upregulating superoxide dismutase and malondialdehyde expression in DBA/1 mice. The MTT, RT-qPCR, and Western blotting results further indicated that STR improved the survival rate of cells by downregulating the expression of target genes in the Wnt/β-catenin pathway and by inhibiting cell inflammation and apoptosis. In conclusion, our findings indicated that STR treatment might be an effective therapeutical strategy for AS.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Applied Mathematics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Modeling and Simulation,General Medicine

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