Myeloid Antigen Expression in Childhood Acute Lymphoblastic Leukemia and Its Relevance for Clinical Outcome in Indonesian ALL-2006 Protocol

Author:

Supriyadi Eddy1,Veerman Anjo J. P.12,Sutaryo 1,Purwanto Ignatius1,vd Ven Peter M.3,Cloos Jacqueline24

Affiliation:

1. Pediatric Hematology Oncology Division, Department of Pediatrics, Dr. Sardjito Hospital, Faculty of Medicine, Universitas Gadjah Mada, Jl. Kesehatan No. 1, Yogyakarta 55281, Indonesia

2. Pediatric Oncology/Hematology Division, Department of Pediatrics, VU University Medical Center, 1007 MB Amsterdam, The Netherlands

3. Department of Epidemiology and Biostatistics, VU University Medical Center, 1007 MB Amsterdam, The Netherlands

4. Department of Hematology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands

Abstract

The frequency of acute lymphoblastic leukemia (ALL) patients expressing myeloid antigens on their ALL cells varies between 5 and 36% in several different studies. The clinical relevance of myeloid antigen expression in childhood ALL is controversial. In Indonesian patients, no data were present. Therefore, in Yogyakarta, Indonesia, we analyzed 239 ALL patients who were immunophenotyped including myeloid markers (CD13, CD33, CD117, and/or cMPO). Myeloid antigen expression was found in 25% of patients. Expression of myeloid antigen in B-lineage leukemia was 27%, and in T-lineage leukemia, it was 18% (P=0.15). No association was found between myeloid antigen expression and clinical or biological features. In the whole cohort of patients we did not find a significant association between myeloid antigen expression and survival, although leukemia-free survival at 3 years was higher in the myeloid-negative patients (73% ± 6%) compared to myeloid-positive patients (67% ± 8%). Interestingly, in T-ALL patients, expression of myeloid antigens was an independent adverse prognostic factor (hazard ratio: 3.26, 95% CI: 1.06–9.98,P=0.04). Kaplan-Meier analysis for event-free survival was also significant (log rankP=0.03) in this subgroup. In conclusion, in the Indonesian ALL population, in particular, myeloid antigen-expressing T-ALL patients had a higher chance of having induction failure.

Publisher

Hindawi Limited

Subject

Oncology

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