Huangqin-Tang and Ingredients in Modulating the Pathogenesis of Ulcerative Colitis

Author:

Wang Chunyan1ORCID,Tang Xudong2ORCID,Zhang Li1ORCID

Affiliation:

1. Institute of Digestive Diseases, China-Canada Center of Research for Digestive Diseases (ccCRDD), Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China

2. Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China

Abstract

Ulcerative colitis (UC) is the most common inflammatory bowel disease worldwide. Current therapies in UC cause limitations, and herb medicine provides an important choice for UC treatment. Huangqin-Tang (HQT) is a well-known classical traditional Chinese herbal formula and has been used in China for thousands of years. A large number of pharmacological studies demonstrated HQT and its ingredients to be effective in treating UC. Though the therapeutic effect has been evaluated, comprehensive up-to-date reviews in this field are not yet available. Here we aim to review our current understanding of HQT and its ingredients in treating UC and how the agents modulate the main pathogenesis of the disease, including the intestinal environment, immune imbalance, inflammatory pathways, and oxidative stress. The summary on this issue may provide better understanding of HQT and its ingredients in treating UC and possibly help in promoting its clinical application.

Funder

Shanghai Rising-Star Program

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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