MiR-9-5p Inhibits the MMP+-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson’s Disease-Reference-Cited by-同舟云学术

MiR-9-5p Inhibits the MMP+-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson’s Disease

Published:2022-04-25 Issue: Volume:2022 Page:1-13
ISSN:1942-0994
Container-title:Oxidative Medicine and Cellular Longevity
language:en
Short-container-title:Oxidative Medicine and Cellular Longevity

Author:

Xiao Zhenyong¹²,Yan Zhenxing¹³,Sun Xiang¹,Zhu Zhiyuan¹,Wang Baoyan¹,Gao Mengqi¹,Lu Fengfei¹,Liu Jian¹,Zong Zhitao⁴^ORCID,Zhang Hongbo¹⁵^ORCID,Guo Yanwu¹^ORCID

Affiliation:

1. Neurosurgery Center, Department of Functional Neurosurgery, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China

2. Department of Neurosurgery, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi, China

3. Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China

4. Department of Neurosurgery, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, Jiangxi 332005, China

5. Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China

Abstract

The pathogenesis of Parkinson’s disease remains unclear that there is no cure for Parkinson’s disease yet. The abnormal expressions of certain miRNA are closely related to the occurrence and progression of Parkinson’s disease. Here, we demonstrate that miR-9-5p inhibits the dopaminergic neuron apoptosis via the regulation of β-catenin signaling which directly targets SCRIB, a tumor suppressor gene. Besides, miR-9-5p improved the motor function of mice with Parkinson’s disease. The results of this study suggest that miR-9-5p might be a potential therapeutic target against Parkinson’s disease.

Publisher

Hindawi Limited

Subject

Cell Biology,Aging,General Medicine,Biochemistry

Link

http://downloads.hindawi.com/journals/omcl/2022/9173514.pdf

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