1. Office of Computational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA
2. Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany
3. Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA
4. Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA