Affiliation:
1. College of Science, Huazhong Agricultural University, Wuhan 430070, China
Abstract
A series of novel cycloalkylthieno[2,3-d]pyrimidinone derivatives have been conveniently synthesizedviathree steps including G-3CR, heterocyclization, and alkylation reactions as a part of our ongoing search for new bioactive molecules. The newly synthesized compounds were evaluated for their potential tumor cell growth inhibitory activity by standard MTT assay. The preliminary results show that compound6bexhibited better inhibitory activities against HepG2, MCF-7, and BCG-823 cell lines compared to the control.
Funder
National Natural Science Foundation of China
Cited by
9 articles.
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