Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency

Author:

Bacalhau Sílvia1,Freitas Cristina1,Valente Rosalina1,Barata Deolinda1,Neves Conceição2,Schäfer Katrin3,Lubatschofski Annelie3,Schulz Ansgar3,Neves João Farela2

Affiliation:

1. Pediatric Intensive Care Unit, Hospital Dona Estefânia, 1169-045 Lisboa, Portugal

2. Infectology Unit, Hospital Dona Estefânia, Rua Jacinta Marto, 1169-045 Lisboa, Portugal

3. Department of Immunology, Rheumatology and Stem Cell Transplantation, University Children's Hospital, 89073-89081 Ulm, Germany

Abstract

In high-burden countries,Mycobacterium bovisBacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severeMycobacterium tuberculosisinfection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against tuberculosis should be redefined in non-high-burden countries. We report the case of a patient with X-linked severe combined immunodeficiency (SCID) who developed disseminated BCG disease, highlighting the specific strategies adopted.

Publisher

Hindawi Limited

Subject

General Medicine

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