Effects of Low-Protein Diets Supplemented with Ketoacid on Expression of TGF-βand Its Receptors in Diabetic Rats

Author:

Yang Xiu1,Yang Ming2,Cheng Ming2,Ma Li-Bin1,Xie Xiang-Cheng1,Han Shuai3,Zhang Bo2,Fei Xiao1,Wang Ming1,Mei Chang-Lin2

Affiliation:

1. Department of Nephrology, Hangzhou First People’s Hospital, Zhejiang 310006, China

2. Department of Nephrology, Changzheng Hospital, Second Military Medical University and the Kidney Institute of CPLA, Shanghai 200003, China

3. Department of Osteology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

Abstract

TGF-β1has been recognized as a key mediator in DN. This study aimed to observe the effects of low-protein diets supplemented with ketoacid on mRNA and protein expression of TGF-βand TβRI and t TβRII receptors in the renal tissue of diabetic rats. A diabetes model was established in 72 male SD rats. They were then equally randomized to three groups: NPD group, LPD group, and LPD + KA group. Additional 24 male SD rats receiving normal protein diets were used as the control. Eight rats from each group were sacrificed at weeks 4, 8, and 12 after treatment, from which SCr, BUN, serum albumin, and 24 h urinary protein excretion were collected. The expressions of TGF-β1, TβRI, and TβRII in LPD and LPD + KA groups were significantly lower than those in NPD group and lower in LPD + KA group than those in LPD group. Low-protein diets supplemented with ketoacid have been demonstrated to provide a protective effect on the renal function as represented by reduced SCr, BUN, and urinary protein excretion, probably through downregulating the gene expression of TGF-β1and its receptors in LPD + KA group.

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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