The Regulatory Effects of MicroRNAs on Tumor Immunity

Author:

Lu Yan1ORCID,Deng Muwen23ORCID,Wang Kang23ORCID,Peng Yuanhong23ORCID,Ouyang Manzhao23ORCID

Affiliation:

1. GCP Center, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan 528300, Guangdong, China

2. Department of Gastrointestinal Surgery, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Shunde, Foshan, Guangdong Province 528300, China

3. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province 510080, China

Abstract

MicroRNAs are endogenous noncoding small RNAs that posttranscriptionally regulate the expressions of their target genes. Accumulating research shows that miRNAs are crucial regulators of immune cell growth and antitumor immune response. Studies on miRNAs and tumors primarily focus on the tumor itself. At the same time, relatively few studies on the indirect regulatory effects of miRNAs in the development of tumors are achieved by affecting the immune system of tumor hosts and altering their immune responses. This review discusses the influence of miRNAs on the antitumor immune system.

Funder

Foshan City’s 13th Five-Year Key Specialty Project

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. MiRNA Immunity Against Virus and MiRNA Surveillance Against Tumor;The MicroRNA Quantum Code Book;2023

2. Tumor-Suppressive and Oncogenic Roles of microRNA-149-5p in Human Cancers;International Journal of Molecular Sciences;2022-09-16

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