Affiliation:
1. Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Private Bag Box 92019, Auckland 1142, New Zealand
2. Department of Molecular Medicine and Pathology, The University of Auckland, Private Bag Box 92019, Auckland 1142, New Zealand
Abstract
Background.The bacteria isolated from severe cases of keratitis and their antibiotic sensitivity are recognised to vary geographically and over time.Objectives.To identify the most commonly isolated bacteria in keratitis cases admitted over a 24-month period to a public hospital in Auckland, New Zealand, and to investigatein vitrosensitivity to antibiotics.Methods.Hospital admissions for culture-proven bacterial keratitis between January 2013 and December 2014 were identified. Laboratory records of 89 culture positive cases were retrospectively reviewed and antibiotic sensitivity patterns compared with previous studies from other NZ centres.Results.From 126 positive cultures, 35 species were identified.Staphylococcuswas identified to be the most common isolate (38.2%), followed byPseudomonas(21.3%). Over the last decade, infection due toPseudomonasspecies, in the same setting, has increased (p≤0.05). Aminoglycosides, cefazolin, ceftazidime, erythromycin, tetracycline, and doxycycline were 100% effective against tested isolatesin vitro. Amoxicillin (41.6%), cefuroxime (33.3%), and chloramphenicol (94.7%) showed reduced efficacy against Gram-negative bacteria, whereas penicillin (51%) and ciprofloxacin (98.8%) showed reduced efficacy against Gram-positive bacteria.Conclusions.Despite a shift in the spectrum of bacterial keratitis isolates, antibiotic sensitivity patterns have generally remained stable and show comparability to results within the last decade from NZ centres.
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献