Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus-Reference-Cited by-同舟云学术

Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus

Published:2016 Issue: Volume:2016 Page:1-8
ISSN:0278-0240
Container-title:Disease Markers
language:en
Short-container-title:Disease Markers

Author:

Ionescu Catalina¹^ORCID,Corbu Catalina Gabriela¹²^ORCID,Tanase Cristiana³⁴^ORCID,Jonescu-Cuypers Christian⁵,Nicula Cristina⁶⁷,Dascalescu Dana¹^ORCID,Cristea Miruna¹^ORCID,Voinea Liliana-Mary²⁸

Affiliation:

1. Clinical Hospital of Ophthalmologic Emergencies (SCUO), Piața Alexandru Lahovari 1, Bucharest, Romania

2. Division of Ophthalmology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, Romania

3. Biochemistry-Proteomics Department, Victor Babes National Institute of Pathology, Sector 5, 050096 Bucharest, Romania

4. Faculty of Medicine, Titu Maiorescu University, Dâmbovnicului Street 22, 040441 Bucharest, Romania

5. Department of Ophthalmology, Charité University Hospital, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany

6. Division of Ophthalmology, Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, Victor Babes Street 8, 400012 Cluj-Napoca, Romania

7. Clinical Emergency Hospital Cluj-Napoca, Clinicilor Street 3-5, 400006 Cluj-Napoca, Romania

8. Department of Ophthalmology, University Emergency Hospital, Splaiul Independenței 169, 050098 Bucharest, Romania

Abstract

Keratoconus is a degenerative disorder with progressive stromal thinning and transformation of the normal corneal architecture towards ectasia that results in decreased vision due to irregular astigmatism and irreversible tissue scarring. The pathogenesis of keratoconus still remains unclear. Hypotheses that this condition has an inflammatory etiopathogenetic component apart from the genetic and environmental factors are beginning to escalate in the research domain. This paper covers the most relevant and recent published papers regarding the biomarkers of inflammation, their signaling pathway, and the potentially new therapeutic options in keratoconus.

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/dm/2016/1243819.pdf

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