The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters-Reference-Cited by-同舟云学术

The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters

Published:2019-06-16 Issue: Volume:2019 Page:1-6
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Tian Bing Ren¹^ORCID,Liu Jia Yue¹,Ge Hu Rong²^ORCID,Wang Zhi Zhong¹^ORCID,Huang Shao Yun²,Wang Yu Ying¹,Huang Qing¹^ORCID,Zhang Rui Xia³^ORCID

Affiliation:

1. School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China

2. Department of Physical Education, Ningxia Medical University, Yinchuan 750004, China

3. Department of Pharmacy, The Third People’s Hospital of Yinchuan, Yinchuan 750004, China

Abstract

A novel series of resveratrol modified by γ-aminobutyric acid esters were designed and synthesized. Then, the products were characterized by 1H-NMR, 13C-NMR, and MS, and the melting point was determined. Molecular water solubility, polar surface area, and octanol-water partition were calculated, which correlated well with molecular transport through membranes and, therefore, enabled prediction of transport properties of drugs.

Funder

Higher Education Institution of Ningxia

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2019/3050486.pdf

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