In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)-Reference-Cited by-同舟云学术

In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)

Published:2019-10-01 Issue: Volume:2019 Page:1-26
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Achakzai Jahangir Khan¹^ORCID,Anwar Panezai Muhammad¹^ORCID,Kakar Abdul Manan¹,Akhtar Basira²,Akbar Ali³^ORCID,Kakar Shahabuddin⁴,Khan Javed⁵,Khan Nazima Yousaf¹,Khan Ghulam Mustafa⁶,Baloch Nizam⁶,Jan Khoso Muhammad Hashim¹,Panezai Marina¹

Affiliation:

1. Institute of Biochemistry, University of Balochistan, Quetta 87300, Pakistan

2. Department of Botany, University of Balochistan, Quetta 87300, Pakistan

3. Department of Microbiology, University of Balochistan, Quetta 87300, Pakistan

4. Department of Zoology, University of Balochistan, Quetta 87300, Pakistan

5. Department of Microbiology, Quaid-i-Azam University, Islamabad 45320, Pakistan

6. Department of Chemistry, University of Balochistan, Quetta 87300, Pakistan

Abstract

In this study, GC-MS analysis has shown that whole plant hexane fraction of Achillea wilhelmsii (WHFAW) consists of 66 compounds which exhibited antileishmanial activity. Antileishmanial bioassay was the method used for determining antileishmanial activity. The inhibitory concentration (IC50) which was observed for whole plant hexane fraction of Achillea wilhelmsii (WHFAW) against parasitic and vector-borne disease, leishmaniasis, is 58.27 ± 0.52 μg/mL. For leishmanicidal assay, Leishmania major is the species used for analysis. Whole plant methanol extract of Achillea wilhelmsii (WMEAW) and whole plant aqueous fraction of Achillea wilhelmsii (WAFAW) exhibited no antileishmanial activity.

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2019/5734257.pdf

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