Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation-Reference-Cited by-同舟云学术

Electronegative LDL: A Circulating Modified LDL with a Role in Inflammation

Published:2013 Issue: Volume:2013 Page:1-13
ISSN:0962-9351
Container-title:Mediators of Inflammation
language:en
Short-container-title:Mediators of Inflammation

Author:

Estruch Montserrat¹²^ORCID,Sánchez-Quesada José Luis¹³,Ordóñez Llanos Jordi²³,Benítez Sònia¹³^ORCID

Affiliation:

1. Servei de Bioquímica, Instituto de Investigaciones Biomédicas Sant Pau (IIB Sant Pau), 167 Sant Antoni Maria Claret, 08025 Barcelona, Spain

2. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain

3. Servei de Bioquímica, Hospital de Sant Pau, 08026 Barcelona, Spain

Abstract

Electronegative low density lipoprotein (LDL(−)) is a minor modified fraction of LDL found in blood. It comprises a heterogeneous population of LDL particles modified by various mechanisms sharing as a common feature increased electronegativity. Modification by oxidation is one of these mechanisms. LDL(−) has inflammatory properties similar to those of oxidized LDL (oxLDL), such as inflammatory cytokine release in leukocytes and endothelial cells. However, in contrast with oxLDL, LDL(−) also has some anti-inflammatory effects on cultured cells. The inflammatory and anti-inflammatory properties ascribed to LDL(−) suggest that it could have a dual biological effect.

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

Link

http://downloads.hindawi.com/journals/mi/2013/181324.pdf

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