Deregulated Expression of Superoxide Dismutase-2 Correlates with Different Stages of Cervical Neoplasia-Reference-Cited by-同舟云学术

Deregulated Expression of Superoxide Dismutase-2 Correlates with Different Stages of Cervical Neoplasia

Published:2011 Issue:6 Volume:30 Page:275-281
ISSN:0278-0240
Container-title:Disease Markers
language:en
Short-container-title:Disease Markers

Author:

Termini Lara¹²,Filho Adhemar Longatto³⁴,Maciag Paulo Cesar²,Etlinger Daniela⁵,Alves Venâncio Avancini Ferreira⁴,Nonogaki Suely⁵,Soares Fernando Augusto⁶⁷,Villa Luisa Lina¹²

Affiliation:

1. Ludwig Institute for Cancer Research – Hospital Alemão Oswaldo Cruz, São Paulo (SP), Brazil

2. HPV Institute – INCT-HPV, Santa Casa de Misericórdia, São Paulo (SP), Brazil

3. Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Campus de Gualtar, Braga, Portugal

4. Laboratory of Medical Investigation (LIM) 14, Department of Pathology, University of São Paulo, School of Medicine, São Paulo(SP), Brazil

5. Pathology Division, Adolfo Lutz Institute, São Paulo (SP), Brazil

6. Department of Anatomic Pathology, Hospital do A. C. Camargo, São Paulo (SP), Brazil

7. Department of General Pathology, Faculty of Dentistry of the University of São Paulo, São Paulo, Brazil

Abstract

Objective: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer.Methods: In the present study, we have evaluated SOD2 protein levels by immunohistochemistry (IHC) in 331 cervical histological samples including 31 low-grade cervical intraepithelial neoplasia (LSIL), 51 high-grade cervical intraepithelial neoplasia (HSIL), 197 squamous cervical carcinomas (SCC) and 52 cervical adenocarcinomas (ADENO).Results: We observed that SOD2 staining increases with cervical disease severity. Intense SOD2 staining was found in 13% of LSIL, 25.5% of HSIL and 40% of SCC. Moreover, 65.4% of ADENO exhibited intense SOD2 staining.Conclusions: Differences in the expression of SOD2 could potentially be used as a biomarker for the characterization of different stages of cervical disease.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/dm/2011/178475.pdf

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. High Levels of Superoxide Dismutase 2 Are Associated With Worse Prognosis in Patients With Breast Cancer;European Journal of Breast Health;2024-07-01

2. Interaction between Cigarette Smoke and Human Papillomavirus 16 E6/E7 Oncoproteins to Induce SOD2 Expression and DNA Damage in Head and Neck Cancer;International Journal of Molecular Sciences;2023-04-07

3. Resveratrol and Cervical Cancer: A New Therapeutic Option;Mini-Reviews in Medicinal Chemistry;2023-02

4. A positive HPV test with positive p16/Ki‐67 double staining in self‐sampled vaginal material is an accurate tool to detect women at risk for cervical cancer;Cancer Cytopathology;2021-08-10

5. High Expression of SOD2 Protein Is a Strong Prognostic Factor for Stage IIIB Squamous Cell Cervical Carcinoma;Antioxidants;2021-05-05