The Role of Suppressors of Cytokine Signalling in Human Neoplasms-Reference-Cited by-同舟云学术

The Role of Suppressors of Cytokine Signalling in Human Neoplasms

Published:2014-03-16 Issue: Volume:2014 Page:1-24
ISSN:2090-2182
Container-title:Molecular Biology International
language:en
Short-container-title:Molecular Biology International

Author:

Sasi Walid¹^ORCID,Sharma Anup K.¹,Mokbel Kefah¹²

Affiliation:

1. St George’s Hospital Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK

2. The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London W1U 5NY, UK

Abstract

Suppressors of cytokine signalling 1–7 (SOCS1–7) and cytokine-inducible SH2-containing protein (CIS) are a group of intracellular proteins that are well known as JAK-STAT and several other signalling pathways negative feedback regulators. More recently several members have been identified as tumour suppressors and dysregulation of their biological roles in controlling cytokine and growth factor signalling may contribute to the development of many solid organ and haematological malignancies. This review explores their biological functions and their possible tumour suppressing role in human neoplasms.

Publisher

Hindawi Limited

Subject

General Economics, Econometrics and Finance

Link

http://downloads.hindawi.com/archive/2014/630797.pdf

Reference320 articles.

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4. The Jak-Stat pathway in normal and perturbed hematopoiesis

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