Unveiling the Role of DNA Methylation in Kidney Transplantation: Novel Perspectives toward Biomarker Identification

Author:

Agodi Antonella1ORCID,Barchitta Martina1ORCID,Maugeri Andrea1ORCID,Basile Guido2,Zamboni Matilde3,Bernardini Giulia3,Corona Daniela3,Veroux Massimiliano1ORCID

Affiliation:

1. Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Via S. Sofia, 87, 95123 Catania, Italy

2. Department of General Surgery and Medical-Surgical Specialties, University of Catania, Via Plebiscito, 628, 95124 Catania, Italy

3. Vascular Surgery Unit, University Hospital of Catania, Via Santa Sofia 87, 95123 Catania, Italy

Abstract

The burden of chronic kidney disease is dramatically rising, making it a major public health concern worldwide. Kidney transplantation is now the best treatment for patients with end-stage renal disease. Although kidney transplantation may improve survival and quality of life, its long-term results are hampered by immune- and/or non-immune-mediated complications. Thus, the identification of transplanted patients with a higher risk of posttransplant complications has become a big challenge for public health. However, current biomarkers of posttransplant complications have a poor predictive value, rising the need to explore novel approaches for the management of transplant patient. In this review we summarize the emerging literature about DNA methylation in kidney transplant complications, in order to highlight its perspectives toward biomarker identification. In the forthcoming future the monitoring of DNA methylation in kidney transplant patients could become a plausible strategy toward the prevention and/or treatment of kidney transplant complications.

Funder

University of Catania, Italy

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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