Electrospray Tandem Mass Spectrometry of 3'-azido-2',3'dideoxythymidine and of a Novel Series of 3'-azido-2',3',4'-trideoxy-4'thio-5-halogenouridines and their Respective α-Anomers-Reference-Cited by-同舟云学术

Electrospray Tandem Mass Spectrometry of 3'-azido-2',3'dideoxythymidine and of a Novel Series of 3'-azido-2',3',4'-trideoxy-4'thio-5-halogenouridines and their Respective α-Anomers

Published:1994 Issue:2 Volume:12 Page:69-83
ISSN:0712-4813
Container-title:Spectroscopy
language:en
Short-container-title:Spectroscopy

Author:

Banoub Joseph¹,Gentil Emmanuel¹,Tber Bougrine²,Fahmi Nour-Eddine²,Ronco Gino²,Villa Pierre²,Mackenzie Grahame³

Affiliation:

1. Northwest Atlantic Fisheries Center, Science Branch, Toxicology Section P.o. Box 5667, AIC 5XI, Canada, and Department of Biochemistry, Memorial University of Newfoundland, st. John's, Newfoundland, AlB 3X9, Canada

2. Laboratoire de Chimie Organique et Cinetique,, UFR des Sciences, Universite de Picardie, 150 rue Saint-Leu, 80000 Amiens, France

3. School of Chemistry, University of Hull, Cottingham, Road, HULL, HU6 7RX, UK

Abstract

Electrospray mass spectrometry has aided the structural characterization of 3'-azido-2',3'-dideoxythymidine (AZI) and the novel series of 3'-azido-2',3',4'trideoxy-4'-thio-S-(bromo, chi oro or fluoro )uridine nucleosides and their respective α.anomers. Low energy CAD MS/MS analysis of the protonated molecules [M+H]+confmned the predicted fragmentation route for AZT and a series of related 4'-thio-S-halogenouridines. This MSIMS study also provided characteristic fingerprint patterns which permitted differentiation of anomers within the series of 3'-azido-2' ,3' ,4' -trideoxy-4' -thio-S-halogenouridine nucleosides.

Publisher

Hindawi Limited

Subject

Spectroscopy

Link

http://downloads.hindawi.com/journals/jspec/1994/817395.pdf

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