The Role of Deubiquitinases in Oncovirus and Host Interactions

Author:

Li Yueshuo123,Shi Feng123,Hu Jianmin123,Xie Longlong123,Bode Ann M.4,Cao Ya12356ORCID

Affiliation:

1. Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410078, China

2. Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha 410078, China

3. Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha 410078, China

4. The Hormel Institute, University of Minnesota, Austin, MN 55912, USA

5. Research Center for Technologies of Nucleic Acid-Based Diagnostics and Therapeutics Hunan Province, Changsha 410078, China

6. Molecular Imaging Research Center of Central South University, Changsha 410008, Hunan, China

Abstract

Infection-related cancer comprises one-sixth of the global cancer burden. Oncoviruses can directly or indirectly contribute to tumorigenesis. Ubiquitination is a dynamic and reversible posttranslational modification that participates in almost all cellular processes. Hijacking of the ubiquitin system by viruses continues to emerge as a central theme around the viral life cycle. Deubiquitinating enzymes (DUBs) maintain ubiquitin homeostasis by removing ubiquitin modifications from target proteins, thereby altering protein function, stability, and signaling pathways, as well as acting as key mediators between the virus and its host. In this review, we focus on the multiple functions of DUBs in RIG-I-like receptors (RLRs) and stimulator of interferon genes (STING)-mediated antiviral signaling pathways, oncoviruses regulation of NF-κB activation, oncoviral life cycle, and the potential of DUB inhibitors as therapeutic strategies.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Oncology

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