Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and β-Adrenergic Stimulation-Reference-Cited by-同舟云学术

Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and β-Adrenergic Stimulation

Published:2017 Issue: Volume:2017 Page:1-7
ISSN:2040-2295
Container-title:Journal of Healthcare Engineering
language:en
Short-container-title:Journal of Healthcare Engineering

Author:

Fassina Lorenzo¹²^ORCID,Cornacchione Marisa³,Pellegrini Manuela⁴⁵,Mognaschi Maria Evelina¹,Gimmelli Roberto⁶,Isidori Andrea Maria⁴,Lenzi Andrea⁴,Magenes Giovanni¹²^ORCID,Naro Fabio⁶^ORCID

Affiliation:

1. Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy

2. Centre for Health Technologies (CHT), University of Pavia, Pavia, Italy

3. IRCCS SDN, Naples, Italy

4. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

5. Institute of Cell Biology and Neurobiology (IBCN), National Research Council (CNR), Rome, Italy

6. Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy

Abstract

In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 μM), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of beating cardiac syncytia starting from the video registration of their contraction movement. We have found that the electromagnetic stimulation is able to counteract the β-adrenergic effect of isoproterenol and to elicit an antihypertrophic response.

Funder

Italian Ministry of University

Publisher

Hindawi Limited

Subject

Health Informatics,Biomedical Engineering,Surgery,Biotechnology

Link

http://downloads.hindawi.com/journals/jhe/2017/4204085.pdf

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