Dampening Host Sensing and Avoiding Recognition inPseudomonas aeruginosaPneumonia

Abstract

Pseudomonas aeruginosais an opportunistic pathogen and causes a wide range of acute and chronic infections.P. aeruginosainfections are kept in check by an effective immune surveillance in the healthy host, while any imbalance or defect in the normal immune response can manifest in disease. Invasive acute infection in the immunocompromised patients is mediated by potent extracellular and cell bound bacterial virulence factors. Life-threatening chronic infection in cystic fibrosis patients is maintained by pathogenic variants that contribute to evade detection and clearance by the immune system. Here, we reviewed the molecular basis of receptor-mediated recognition ofP. aeruginosaand their role in initiating inflammation and the colonization. In addition, the consequence of theP. aeruginosagenetic adaptation for the antibacterial defence and the maintaining of chronic infection are discussed.