Stability Analysis of Mathematical Model including Pathogen-Specific Immune System Response with Fractional-Order Differential Equations

Abstract

In this study, the mathematical model examined the dynamics between pathogen and specific immune system cells (memory T cells) for diseases such as chronic infection and cancer in which nonspecific immune system cells are inadequate to destroy the pathogen and has been suggested by using a system of the fractional-order differential equation with multi-orders. Qualitative analysis of the proposed model reveals the equilibrium points giving important ideas about the proliferation of the pathogen and memory T cells. According to the results of this analysis, the possible scenarios are as follows: the absence of both pathogen and memory T cells, only the existence of pathogen, and the existence of both pathogen and memory T cells. The qualitative analysis of the proposed model has expressed the persistent situations of the disease where the memory T cells either do not be able to respond to the pathogen or continue to exist with the disease-causing pathogen in the host. Results of this analysis are supported by numerical simulations. In the simulations, the time-dependent size of the tumor population under the pressure of the memory T cells was tried to be estimated.