Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids-Reference-Cited by-同舟云学术

Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids

Published:2014-11-19 Issue: Volume:2014 Page:1-14
ISSN:2090-0104
Container-title:Journal of Amino Acids
language:en
Short-container-title:Journal of Amino Acids

Author:

Ravi Kumar P.¹²,Behera Manoranjan¹^ORCID,Sambaiah M.¹,Kandula Venu¹,Payili Nagaraju¹,Jaya Shree A.²,Yennam Satyanarayana¹

Affiliation:

1. Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., Plot No. 28, IDA, Nacharam, Hyderabad, Andhra Pradesh 500 076, India

2. Centre for Chemical Sciences & Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Andhra Pradesh 500 072, India

Abstract

A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). Using this method, for the first time various isoxazole tethered quinone-phenyl alanine and quinone-alanine hybrids were synthesized from simple commercially available 4-bromobenzyl bromide, propargyl bromide, and 2,5-dimethoxybenzaldehyde in good yield.

Funder

GVK Biosciences Private Limited

Publisher

Hindawi Limited

Subject

Molecular Biology,Biochemistry,Molecular Biology,Biochemistry

Link

http://downloads.hindawi.com/archive/2014/721291.pdf

Reference50 articles.

1. Occurrence, biosynthesis and function of isoprenoid quinones

2. Role of the semi-quinone free radical of the anti-tumour agent etoposide (VP-16-213) in the inactivation of single- and double-stranded ΦX174 DNA

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