Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children-Reference-Cited by-同舟云学术

Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children

Published:2022-03-04 Issue: Volume:2022 Page:1-4
ISSN:1748-6718
Container-title:Computational and Mathematical Methods in Medicine
language:en
Short-container-title:Computational and Mathematical Methods in Medicine

Author:

Cheng Yanli¹,Hao Guoping¹^ORCID,Wang Xiaohuan¹,Lu Haiyan¹,Wang Jing¹,Suo Taoli¹,Hou Zhaohui¹,Guo Huimin²,Zhang Shixun³

Affiliation:

1. Department of Hematology, Shanxi Children’s Hospital, China

2. Scientific Research Department of Clinical Laboratory Center of Shanxi Children’s Hospital, China

3. Bone Marrow Laboratory of Shanxi Children’s Hospital, China

Abstract

Objective. To investigate the role and mechanism of lncRNA-pvt1 in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). Methods. The expression of lncRNA-pvt1 in bone marrow tissues of ALL patients after initial diagnosis and complete remission was detected by RT-PCR to explore its possible involvement in the pathogenesis of ALL. The proliferation and apoptosis of Jurkat cells transfected with lncRNA-pvt1 were observed by MTT and flow cytometry. Results. lncRNA-pvt1 expression was upregulated in bone marrow of ALL patients. Knockdown of lncRNA-pvt1 inhibited Jurkat cell proliferation and increased its apoptosis rate. Conclusion. Silencing lncRNA-pvt1 expression can inhibit the development of ALL.

Funder

Scientific Research Project of Shanxi Provincial Health Commission

Publisher

Hindawi Limited

Subject

Applied Mathematics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Modeling and Simulation,General Medicine

Link

http://downloads.hindawi.com/journals/cmmm/2022/8955322.pdf

Reference20 articles.

1. Acute Myeloid Leukemia — Many Diseases, Many Treatments

2. Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

3. A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

4. Long Noncoding RNA PVT1 Promotes Melanoma Progression via Endogenous Sponging miR-26b

5. Construction of differential mRNA-lncRNA crosstalk networks based on ceRNA hypothesis uncover key roles of lncRNAs implicated in esophageal squamous cell carcinoma

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Retracted: Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children;Computational and Mathematical Methods in Medicine;2023-06-28