Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats

Author:

Hsu Chuan-Chih12,Chen Li-Fan34,Lin Mao-Tsun5,Tian Yu-Feng67ORCID

Affiliation:

1. Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 112, Taiwan

2. Division of Cardiovascular Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei 112, Taiwan

3. Nursing Department, Cheng Kung University Hospital, Tainan 701, Taiwan

4. Department of Nursing, Chang Jung Christian University, Tainan 712, Taiwan

5. Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan

6. Department of Surgery, Chi Mei Medical Center, Tainan 710, Taiwan

7. Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 712, Taiwan

Abstract

We aimed at investigating the effect of honokiol on heatstroke in an experimental rat model. Sprogue-Dawley rats were divided into 3 groups: normothermic diabetic rats treated with vehicle solution (NTDR+V), heatstroke-diabetic rats treated with vehicle (HSDR+V), and heatstroke rats treated with konokiol (0.5–5 mg/ml/kg) (HSDR+H). Sixty minutes before the start of heat stress, honokiol or vehicle solution was administered. (HSDR+H) significantly (a) attenuated hyperthermia, hypotension and hypothalamic ischemia, hypoxia, and neuronal apoptosis; (b) reduced the plasma index of the toxic oxidizing radicals; (c) diminished the indices of hepatic and renal dysfunction; (d) attenuated the plasma systemic inflammatory response molecules; (e) promoted plasma levels of an anti-inflammatory cytokine; (f) reduced the index of infiltration of polymorphonuclear neutrophils in the serum; and (g) promoted the survival time fourfold compared with the (HSDR+V) group. In conclusion, honokiol protected against the outcome of heatstroke by reducing inflammation and oxidative stress-mediated multiple organ dysfunction in diabetic rats.

Publisher

Hindawi Limited

Subject

Endocrine and Autonomic Systems,Endocrinology,Endocrinology, Diabetes and Metabolism

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