Arterial Tortuosity and Its Correlation with White Matter Hyperintensities in Acute Ischemic Stroke

Author:

Shang Ke1,Chen Xiao2,Cheng Chang1,Luo Xiang1,Xu Shabei1,Wang Wei1,Liu Chenchen1ORCID

Affiliation:

1. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

2. Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Abstract

Introduction. The association between arterial tortuosity and acute ischemic stroke (AIS) has been reported, but showing inconsistent results. We hypothesized that tortuosity of extra- and intracranial large arteries might be higher in AIS patients. Furthermore, we explored the correlation between artery tortuosity and white matter hyperintensity (WMH) severity in AIS patients. Methods. 166 AIS patients identified as large artery atherosclerosis, and 83 control subjects were enrolled. All subjects received three-dimensional computed tomography angiography (CTA). Arterial tortuosity was evaluated using the tortuosity index. WMHs were evaluated using magnetic resonance imaging in all AIS patients. Results. AIS patients showed significantly increased arterial tortuosity index relative to controls, including left carotid artery (CA) ( p = 0.001 ), right CA ( p < 0.001 ), left common carotid artery (CCA) ( p < 0.001 ), right CCA ( p < 0.001 ), left internal carotid artery ( p = 0.001 ), right internal carotid artery ( p = 0.01 ), left extracranial internal carotid artery (EICA) ( p < 0.001 ), right EICA ( p = 0.01 ), and vertebral artery dominance (VAD) ( p = 0.001 ). The tortuosity of all above arteries was associated with the presence of AIS. AIS patients with moderate or severe WMHs had a higher tortuosity index in left CA ( p = 0.005 ), left CCA ( p = 0.003 ), left EICA ( p = 0.07 ), and VAD ( p = 0.001 ). In addition, the tortuosity of left EICA and VAD was associated with WMH severity in AIS patients. Conclusions. Increased extra- and intracranial large arteries tortuosity is associated with AIS. The tortuosity of left carotid artery system and vertebral artery may be the independent risk factors for WMH severity in AIS patients. Clinical Trial Registration. This trial is registered with NCT03122002 (http://www.clinicaltrials.gov).

Funder

Tongji Hospital Clinical Research Flagship Program

Publisher

Hindawi Limited

Subject

Neurology (clinical),Neurology

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3