Hematopoietic Stem Cell Development, Niches, and Signaling Pathways-Reference-Cited by-同舟云学术

Hematopoietic Stem Cell Development, Niches, and Signaling Pathways

Published:2012-07-30 Issue: Volume:2012 Page:1-16
ISSN:2090-2999
Container-title:Bone Marrow Research
language:en
Short-container-title:Bone Marrow Research

Author:

Chotinantakul Kamonnaree¹²,Leeanansaksiri Wilairat¹²

Affiliation:

1. Stem Cell Therapy and Transplantation Research Group, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand

2. School of Microbiology, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand

Abstract

Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions mainly in homeostasis and immune response. HSCs transplantation has been applied for the treatment of several diseases. However, HSCs persist in the small quantity within the body, mostly in the quiescent state. Understanding the basic knowledge of HSCs is useful for stem cell biology research and therapeutic medicine development. Thus, this paper emphasizes on HSC origin, source, development, the niche, and signaling pathways which support HSC maintenance and balance between self-renewal and proliferation which will be useful for the advancement of HSC expansion and transplantation in the future.

Publisher

Hindawi Limited

Subject

Cell Biology,Hematology,Immunology

Link

http://downloads.hindawi.com/archive/2012/270425.pdf

Reference171 articles.

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3. CD133+ human umbilical cord blood stem cells enhance angiogenesis in experimental chronic hepatic fibrosis

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