Ameliorated Stomach Specific Floating Microspheres for Emerging Health Pathologies Using Polymeric Konjac Glucomannan-Based Domperidone

Abstract

The goal of this study was to use polymeric konjac glucomannan (KGM), Kollidon VA 64 (KVA64), and glutaraldehyde to ameliorate stomach specific floating microspheres (SSFM) using domperidone (DoN) to increase in vivo bioavailability and emerging health pathologies. The SSFM were made using the emulsion cross-linking process, and the polymer was chosen based on its ability to get cross-linked. The thermodynamic parameters were used to determine the AL classes of phase solubility curves using ideal complexes produced with KVA64. The optimal interaction constants at 25 and 37°C were found to be 116.14 and 128.05 M-1, respectively. The prepared SSFM had an average particle size (PS) of $163.71\pm 2.26$  mm and a drug content of $96.66\pm 0.32$ %. It can be determined from in vitro drug release experiments that drug release is good in terms of regulated drug release after 12 h ( $92.62\pm 2.43$ %). The SSFMs were approximately sphere-shaped and had smooth surfaces, according to the morphological data. SSFMs were investigated using Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and differential scanning calorimetry (DSC), and no chemical structural changes were identified. The SSFMs produces a considerable gastric residence time with optimal DoN release and absorption in stomach fluid, and the mean residence time ( $17.36\pm 1.4$  h) and $t_{1/2}$ ( $10.47\pm 0.6$  h) were considerably longer ( $p<0.05$ ) than those obtained following i.v. treatment ( $\text{MRT}=8.42\pm 1.2$  h; $t_{1/2}=9.07\pm 0.7$  h). The SSFMs maintained good physical stability for three months when stored at room temperature.